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. 2022 Mar 29;97(2):174–186. doi: 10.1111/cen.14710

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© 2022 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Adrenal, ovarian and peripheral androgen metabolism. Both classic and 11‐oxygenated androgen pathways are demonstrated. Androgenic precursors are secreted predominantly by the adrenal glands and activated to potent androgens in the ovaries and peripheral tissues. 5αR 1/2, 5α‐reductase type 1 and 2; 11OHA4, 11β‐hydroxyandrostenedione; 11OHT, 11β‐hydroxytestosterone; 11OHDHT, 11‐hydroxydihydrotestosterone; 11KA4, 11‐ketoandrostenedione; 11KT, 11‐ketotestosterone; 11KDHT, 11‐ketodihydrotestosterone; 17OHP, 17‐hydroxyprogesterone; A4, androstenedione; AKR1C3, aldoketoreductase type 1C3; CYP11B1, 11β‐hydroxylase type 1; DHEA, dehydroepiandrosterone; DHT, dihydrotestosterone; T, testosterone [Color figure can be viewed at wileyonlinelibrary.com]