TABLE 1.

Potential ^a features of ‘magnet’ and ‘bomb’ patients with type‐2 high asthma

Magnet‐driven T2 asthma	Bomb‐driven T2‐asthma
Early onset	Late onset
Allergy	No allergy
AHR++	Less AHR
Eczema, atopic rhinitis/CRSwNP	Less atopic CRSwNP, EGPA
FeNO signal > blood eos signal	Blood eos signal > FeNO signal
ICS > OCS sensitivity	OCS > ICS sensitivity
Anti‐TSLP/anti‐IL‐4Rα > anti‐IL‐5 response	Anti‐IL‐5 ~ anti‐IL‐4Rα > anti‐TSLP response

Note: Magnet patients have earlier onset, allergic asthma characterized by more airway hyperresponsiveness, more allergy and allergy‐associated comorbidities and a more compete response to ICS and anti‐TSLP/anti‐IL‐4Rα.

Abbreviations: AHR, airway hyperresponsiveness; CRSwNP, chronic rhinosinusitis and nasal polyposis; EGPA, eosinophilic granulomatosis and polyangiitis; eos, eosinophils; FeNO, fractional exhaled nitric oxide; ICS, inhaled corticosteroids; IL‐4Rα, IL‐4 receptor‐alpha; OCS, oral corticosteroids; TSLP, thymic stromal lymphopoietin.

^a The table is speculative based on the data discussed in full body.