TABLE 1.
Demographic and clinical data for 6945 patients operated on for colorectal cancer in 21 different hospitals from 2007 to 2012 in Sweden, with NSAID use according to each hospital's ERAS or ERAS‐like programme as exposure
| Variables | Presumed postoperative NSAID use (N = 6945) | ||
|---|---|---|---|
| No (n = 2949) | Yes (n = 3996) | Missing | |
| Categorical | n (%) | n (%) | n (%) |
| Sex | |||
| Male | 1588 (53.9) | 2084 (52.2) | 0 (0) |
| Female | 1361 (46.2) | 1912 (47.9) | |
| ASA classification | |||
| I | 631 (21.4) | 852 (21.3) | 127 (1.8) |
| II | 1741 (59.0) | 2230 (55.8) | |
| III | 555 (18.8) | 809 (20.3) | |
| BMI (kg/m2) | |||
| <20 | 136 (4.6) | 212 (5.3) | 563 (8.1) |
| 20–25 | 1084 (36.8) | 1375 (34.4) | |
| 25.01–30 | 1035 (35.1) | 1493 (37.4) | |
| >30 | 453 (15.4) | 594 (14.9) | |
| cTNM | |||
| I | 537 (18.2) | 622 (15.6) | 3064 (44.1) |
| II | 528 (17.9) | 636 (15.9) | |
| 716 (24.3) | 842 (21.1) | ||
| pTNM | |||
| I | 586 (19.9) | 911 (22.8) | 122 (17.6) |
| II | 1177 (39.9) | 1601 (40.1) | |
| III | 1147 (38.9) | 1401 (35.1) | |
| Diverting stoma | |||
| No | 2169 (73.6) | 2907 (72.8) | 11 (0.2) |
| Yes | 774 (26.3) | 1084 (27.1) | |
| Neoadjuvant therapy | |||
| None | 2362 (80.3) | 3211 (80.5) | 0 (0) |
| Radiotherapy | 419 (14.3) | 605 (15.2) | |
| Chemoradiotherapy | 160 (5.4) | 174 (4.4) | |
| Planned or emergent procedure | |||
| Planned | 2756 (93.6) | 3713 (93.0) | 9 (0.1) |
| Emergent | 187 (6.6) | 280 (7.0) | |
| Tumour location | |||
| Right | 1120 (38.0) | 1547 (38.7) | 2 (0.0) |
| Left | 971 (32.9) | 1323 (33.1) | |
| Rectum | 856 (29.0) | 1126 (28.2) | |
| Anastomotic location | |||
| Ileo‐colic | 1028 (34.9) | 1397 (35.0) | 0 (0) |
| Colo‐colic | 763 (25.9) | 1113 (27.9) | |
| Colo‐/ileo‐rectal | 1158 (39.3) | 1486 (37.2) | |
| Adjuvant therapy | |||
| No | 1971 (66.8%) | 2569 (64.3%) | 79 (1.1) |
| Yes | 939 (31.8%) | 1387 (34.7%) | |
| Continuous | Median (IQR) | Median (IQR) | Missing, n (%) |
|---|---|---|---|
| Age (years) | 68 (61–74) | 68 (62–74) | 1 (0.0) |
| Intraoperative bleeding (ml) | 200 (100–500) | 200 (100–400) | 268 (3.9) |
| Year of surgery | 2010 (2008–2011) | 2009 (2008–2011) | 0 (0) |
| Hospital volume (resections/year) | 57 (43.5–124.5) | 59.7 (43.3–67.8) | 0 (0) |
Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index; cTNM, clinical tumour stage; IQR, interquartile range; NSAID, nonsteroidal anti‐inflammatory drug; pTNM, pathological tumour stage.