TABLE 4.
Anastomotic leakage as outcome for 6945 patients operated on for colorectal cancer between 2007and 2012 in 21 hospitals in Sweden, where the exposed patients were operated on at hospitals that used NSAIDs in their postoperative analgesia protocols
| Anastomotic location | No. of leakages in exposed (%) | No. of leakages in nonexposed (%) | Unadjusted OR (95% CI) for anastomotic leakage | Adjusted a OR (95% CI) for anastomotic leakage |
|---|---|---|---|---|
| All locations | 188 (4.7) | 182 (6.2) | 0.71 (0.53–0.96) | 0.69 (0.51–0.94) |
| Ileo‐colic | 42 (3.0) | 27 (2.6) | 1.07 (0.63–1.83) | 1.08 (0.63–1.85) |
| Colo‐colic | 61 (5.5) | 36 (4.7) | 1.11 (0.69–1.79) | 1.20 (0.74–1.93) |
| Colo‐/ileo‐rectal | 85 (5.7) | 119 (10.3) | 0.51 (0.36–0.72) | 0.47 (0.33–0.68) |
Abbreviations: CI, confidence interval; OR, odds ratio; NSAID, nonsteroidal anti‐inflammatory drug.
Multivariable logistic regression was used to derive ORs with 95% CIs.
a
With adjustment for American Society of Anesthesiologists class, age, body mass index, intraoperative bleeding, diverting stoma, hospital volume, neoadjuvant therapy, emergency procedure, sex, anastomotic location and year of surgery.