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. 2022 Oct 3;15:5813–5829. doi: 10.2147/IDR.S378157

Table 1.

Several Characterized Type II TA Modules Involve in Salmonella Persistence

TA Module Predicted Mechanism of Toxin Activity Molecular Class of Toxin Cellular Target References
ShpAB Protein translation inhibition: cleave mRNA RelE-like RNases mRNA [22]
VapBC Protein translation inhibition: cleave initiator tRNA PIN-domain ribonucleases tRNAfMet [97,101,103]
TacAT Protein translation inhibition: acetylating aminoacyl-tRNA GNAT tRNA(gly) [23,84,102]
TacAT2 Protein translation inhibition: acetylating aminoacyl-tRNA GNAT tRNA [23,84]
TacAT3 Protein translation inhibition: acetylating aminoacyl-tRNA GNAT tRNA [23,84]