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. 2022 Apr 25;88(9):4121–4133. doi: 10.1111/bcp.15349

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© 2022 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Association between hepatic (A) CYP1A2, (B) CYP2C19 and (C) CYP2C9 concentrations and respective metabolic ratios at the time of surgery for patients subjected to RYGB (week 3) or cholecystectomy (week 0). Spearman's rho (ρ) is the correlation coefficient. P values are from the Spearman rank correlation analysis. CYP, cytochrome P450; LCA, losartan carboxylic acid. Two patients were not able to supply metabolic ratios (RYGB = 2) due to technical difficulties. Due to visualization purposes, one losartan/LCA ratio in the control group (49.05) was excluded from plot (C)