Author/Year/Title |
Study Design |
Study Population and characteristics |
Sample Size |
Summary (Based on the 3 Objectives) |
1. Jongsma HE et al., 2017 [1] |
Systematic review and meta-analysis. |
Individuals with non-organic adult onset psychosis. |
-177 . |
The global incidence of psychotic disorders is 26.6 per 100000 person-years. |
2. Burns AMN et al., 2014 [2] |
Meta-analysis |
Individuals exhibiting symptoms of psychosis despite adequate trials of medication. |
639 |
CBT is beneficial in the management of medication-resistant psychosis. |
3. Wykes T et al., 2022 [3] |
Meta-analysis |
Individuals suffering from schizophrenia with symptoms. |
34 CBTp trials. |
CBT can be offered as a group and It is effective in improving symptoms of schizophrenia. |
4. Stafford MR et al., 2022 [4] |
Systematic review and meta-analysis. |
Individuals at risk without a formal diagnosis of bipolar disorder or schizophrenia |
11 trials including 1246 participants. |
It may be possible to delay or prevent transition to psychosis with CBT in individuals at risk. |
5. Van der Gaag M et al., 2019 [5] |
Systematic review |
Patients with ‘at-risk mental state’ (ARMS) |
|
CBTp can be used in at-risk mental state patients to prevent transition to first episode psychosis. More effective in this group because they still have ‘insight’ as compared to frank psychosis |
6. Ising HK et al., 2017 [6] |
Randomised control trial |
-14-35 years - Family history of psychosis or Comprehensive Assessment of At-Risk Mental States (CAARMS). |
196 |
CBTuhr had an 83% likelihood of resulting in a reduction of the transition to psychosis at a lower cost. |
7. Morrison AP et al., 2019 [7] |
|
People with Clozapine Resistant Schizophrenia aged ≥ 16 years, with an ICD-10 schizophrenia spectrum diagnoses and who are experiencing psychotic symptoms. |
487 [242 were allocated to CBT + TAU and 245 to TAU(Treatment as Usual)] |
-Cognitive behavioural therapy for CRS was not found superior to TAU at 21 months, but was superior at 9 months (end of treatment). -CBT resulted in improved quality of life with a net QALY gain of 0.052 compared with the usual treatment -Study reported that there was no suggestion that the addition of CBT to TAU caused adverse effects. CGI group reported 33 voluntary and 10 involuntary hospitalizations while TAU reported 24 and 14 respectively. -CBT was not found to be cost-effective in comparison with TAU. |
8. Wijnen BFM et al., 2018 [8] |
Randomised control trial |
Single-blinded randomized control trial between treatment-as-usual group versus treatment-as-usual augmented with adjunct CBTsa |
50 participants in treatment-as-usual group and 49 participants in treatment -as-usual with adjunctive CBTsa |
Found higher costs as compared to treatment-as-usual, as much as 20000-80000euros to achieve 1 QALY |
9. Sheaves B et al., 2019 [9] |
Randomized control trial |
NA |
-feasibility outcomes assessed therapy uptake, techniques used, satisfaction, and attrition. -The primary efficacy outcome assessed nightmare severity at week |
-CBT for nightmares is feasible and may be efficacious for treating nightmares and comorbid insomnia for patients with persecutory delusions. -It shows promise on paranoia but potentially not on suicidal ideation. |
10. Liu Y et al., 2019 [10] |
Randomized control trial |
-Participants recruited from Beijing Anding hospital affiliate between June 2012 and march 2014. -Participants randomized to a CBTp plus treatment-as-usual group or just a treatment-as-usual group |
80 |
Brief CBTp targeting positive symptoms was effective in first-episode schizophrenia |
11. Waller H et al., 2015 [11] |
Randomized controlled trial |
Participants with persistent, stable persecutory delusions were recruited from adult community mental health teams |
|
-In CBT arm the participants underwent the Thinking Well intervention in which they first completed the Maudsley Review Training Programme (MRTP) followed by four individualised CBT sessions. -Clinically beneficial effects were seen for belief flexibility, state paranoia and on distress and conviction. |
12. Muller H et al., 2020 [12] |
Randomized controlled trial |
Adolescents with early onset psychosis |
25 at the start (CBT +TAU =13, TAU=12) Lost to follow up=9 |
-There were no statistically significant differences between the two treatment arms post-treatment on any of the psychopathology, functional, remission measures but , CBT+TAU showed a significantly higher score on the “material quality of life” subscale -There were seven hospital admissions during the time of intervention: only two of them belonged to the CBT+TAU group, whereas five participants of TAU were hospitalized. |
13. Freeman D et al., 2014 [13] |
Randomized controlled trial |
Patients with current persecutory delusions |
30 (15 were allocated to CBT + standard care and 15 to standard care) |
-The study reported improvement in psychological well-being, positive beliefs about the self, negative social comparison, self-esteem, and depression. -Post treatment there was a small reduction in negative self-beliefs and a moderate reduction in paranoia but these were not statistically significant. |
14. Sönmez N et al., 2019 [14] |
Randomized control trial |
Early psychosis patients were included and randomly assigned to receive either CBT (maximum 26 sessions) or TAU for a period of up to six months. |
63 |
They did not find CBT to be more effective than TAU in reducing depressive symptoms or increasing self-esteem in patients with early psychosis. However, CBT seems to improve negative symptoms and functioning. |
15. Granholm E et al., 2014 [15] |
Randomized control trial |
-Participants were recruited through flyers and brochures posted and handed out by a study recruiter at a variety of community |
149 . |
The results suggest CBSST is an effective treatment to improve functioning and experiential negative symptoms in consumers with schizophrenia, and both CBSST and supportive group therapy actively focused on setting and achieving functioning goals can improve social competence and reduce positive symptoms. |
16. Fitriani N et al., 2021 [16] |
Quasi-experimental without control group. 4 sessions of CBT and 5 sessions of social skill training , using patients’ schizophrenia workbooks and diaries |
74 patients with schizophrenia. |
30 patients were sampled using consecutive sampling technique |
Combination of CBT and SST has positive changes in the sign and symptoms of risk for violent behaviour patients with schizophrenia, and these changes impact the ability of patients to control their symptoms |
17. Brabban A et al., 2022 [17] |
Randomized control trial |
Patients aged 18-65 years who had a formal diagnosis of Schizophrenia and who were receiving care from secondary mental health services. |
354 . |
-CBT improves psychosis in Schizophrenia. -Being female led to a 25% increase in Insight and reduction in overall symptoms following CBT |
18. Xanidis N et al., 2020 [18] |
Qualitative study with focus groups and individual interviews |
Members of staff working in the community and crisis mental health teams. Mental health nurses (n = 5), consultant psychiatrists (n = 2), clinical/counselling psychologists (n = 2), CBT therapists (n = 2), an occupational therapist (n = 1), a team leader (n = 1), and a senior adult mental health manager (n = 1). |
The results of this study suggested a mixture of barriers and facilitators to CBTp implementation. |
-Challenges that physicians face while applying CBTp are the intensity of symptoms and reported lack of insight of patients with psychosis. Furthermore, difficulties with consistent attendance enhanced experts' pessimism about the feasibility of recovery and reinforced the lack of implementation. -In addition, Professionals are unable to apply CBTp due to a high caseload, a lack of protected time, and supervision. |
19. Kopelovich SL et al., 2019 [19] |
Prospective study with administration of a learning collaborative (LC) model and a biweekly phone-based follow-up over a six- month period. Additional six month follow-up for 21 of the persons after phase 1 |
psychotic volunteers from 12 different agencies across Florida state |
56 |
-Low implementation of CBTp due to resource limitation. Recommended brief CBTp targeting specific symptoms as a measure to address this challenge. Also noted reduction in relapse with brief CBTp |
20. Grossi LM et al., 2021 [20] |
Systematic review |
NA |
NA |
-CBTp can be used to restore and ensure durability of competency in psychotic suspects. -It can be used in traditional treatment-refractory cases in the face of compliance with medications. |
21. Dunn G et al., 2012 [21] |
Randomized control trial |
NA |
133 |
-Consistent delivery of full therapy, including specific cognitive and behavioural techniques, was associated with clinically and statistically significant increases in months in remission, and decreases in psychotic and affective symptoms. -CBT-P is of significant benefit on multiple outcomes to patients able to engage in the full range of therapy procedures. The novel statistical methods illustrated in this report have general application to the evaluation of heterogeneity in the effects of treatment. |