Fixed effects: IS ~ time * Intervention + Sex + Age + Mobility + Barthel_T01 + Epilepsy
	Value	Std. error	DF	t value	P value
(Intercept)	0.3730249	0.26048541	117	1.4320376	0.1548
time	0.0057876	0.00242831	117	2.3833700	0.0188
Intervention	0.1072920	0.04184390	117	2.5641022	0.0116
Sex female	0.0403991	0.04829016	31	0.8365910	0.4092
Age	0.0012538	0.00305032	31	0.4110536	0.6839
Mobility with support	−0.0756427	0.07959848	31	−0.9503031	0.3493
Mobility wheelchair	0.0516261	0.09218538	31	0.5600252	0.5795
Barthel_T01	0.0114818	0.00590995	31	1.9428009	0.0612
Epilepsy	−0.0828045	0.06319795	31	−1.3102411	0.1997
time:intervention	−0.0082066	0.00273661	117	−2.9988331	0.0033

Fixed effects: IV ~ ns(time, df = 2) * Intervention + Sex + Age + Mobility + Barthel_T01 + Lawton_T01 + Epilepsy + Beta blockers
	Value	Std. error	DF	t value	P value
(Intercept)	0.6988945	0.3493700	115	2.000442	0.0478
ns(time, df = 2)1	0.1523786	0.2090815	115	0.728800	0.4676
ns(time, df = 2)2	0.6164107	0.4465877	115	1.380268	0.1702
Intervention	−0.5087580	0.2311909	115	−2.200597	0.0298
Sex	10.0475728	0.0655067	29	0.726227	0.4735
Age	0.0022832	0.0041903	29	0.544877	0.5900
Mobility with support	0.1702592	0.1074155	29	1.585053	0.1238
Mobility wheelchair	−0.1518288	0.1384362	29	−1.096742	0.2818
Barthel_T01	−0.0342962	0.0095723	29	−3.582860	0.0012
Lawton_T01	0.0217176	0.0137927	29	1.574574	0.1262
Epilepsy	0.3356144	0.0897508	29	3.739402	0.0008
Beta blockers	−0.1127678	0.0972523	29	−1.159539	0.2557
ns(time, df = 2)1:Intervention	0.7068088	0.4530172	115	1.560225	0.1215
ns(time, df = 2)2:Intervention	−0.4399246	0.4513825	115	−0.974616	0.3318

Fixed effects: SOT ~ ns(date, df = 2) * Intervention + Age + Sex + Barthel_T01 + Daily activities (hours per week) + Benzodiazepines + Antipsychotics + Anti epileptics + Epilepsy + Hearing impairment + Genetic syndrome ID + Level of ID + Beta blockers
	Value	Std. error	DF	t value	P value
(Intercept)	87341.99	6805.054	922	12.834871	0.0000
ns(date value, df = 2)1	−2187.33	2873.951	922	−0.761089	0.4468
ns(date value, df = 2)2	−14789.27	6621.930	922	−2.233378	0.0258
Intervention1	4155.90	3884.406	922	1.069894	0.2849
Age	−104.77	73.304	22	−1.429282	0.1670
Sex1	−1191.37	1226.445	22	−0.971403	0.3419
Barthel_T01	252.92	105.624	22	2.394513	0.0256
Daily activities (hours per week)	−97.85	74.410	22	−1.315022	0.2020
Benzodiazepines yes	1730.18	1287.872	22	1.343439	0.1928
Antipsychotics	−2706.55	1188.428	22	−2.277418	0.0328
Antiepileptics	−1815.25	2119.905	22	−0.856289	0.4011
Epilepsy	−468.14	1885.187	22	−0.248326	0.8062
Hearing impairment	267.77	658.602	22	0.406580	0.6882
Genetic syndrome Down syndrome	−194.71	1673.428	22	−0.116352	0.9084
Genetic syndrome Fragile X	−888.29	3734.738	22	−0.237846	0.8142
Genetic syndrome no/unknown	62.63	2611.155	22	0.023986	0.9811
Level of moderate	−3796.38	1819.229	22	−2.086809	0.0487
Level of severe	−1771.41	1609.971	22	−1.100272	0.2831
Level of ID unknown	−9876.22	5522.385	22	−1.788397	0.0875
Beta blockers1	199.61	1686.169	22	0.118381	0.9068
ns(date, df = 2)1:Intervention	−4000.21	7323.613	922	−0.546208	0.5851
ns(date, df = 2)2:Intervention	14325.53	6726.808	922	2.129618	0.0335

Fixed effects: Mid‐sleep ~ ns(date, df = 2) * Intervention + Age + Sex + Lawton_T01 + Barthel_T01 + Daily activities (hours per week) + Benzodiazepines + Antipsychotics + Antiepileptics + Beta blockers + Hearing impairment
	Value	Std. error	DF	t value	P value
(Intercept)	101858.58	5129.496	922	19.857426	0.0000
ns(date, df = 2)1	−1135.57	2038.615	922	−0.557031	0.5776
ns(date, df = 2)2	−8775.37	4687.883	922	−1.871927	0.0615
Intervention	3423.16	2884.311	922	1.186822	0.2356
Age	−20.63	59.139	28	−0.348836	0.7298
Sex female	34.74	1066.316	28	0.032577	0.9742
Lawton_T01	−239.91	178.432	28	−1.344545	0.1896
Barthel_T01	63.58	106.358	28	0.597759	0.5548
Daily activities (hours per week)	−128.47	58.589	28	−2.192769	0.0368
Benzodiazepines	1815.18	974.812	28	1.862085	0.0731
Antipsychotics	−1343.87	1042.558	28	−1.289009	0.2079
Antiepileptics	−1395.43	1670.243	28	−0.835464	0.4105
Beta blockers	−182.78	1361.328	28	−0.134266	0.8942
Hearing impairment	−85.20	344.043	28	−0.247646	0.8062
ns(date, df = 2)1:Intervention	−4191.01	5564.238	922	−0.753205	0.4515
ns(date, df = 2)2:Intervention	8367.79	4842.570	922	1.727966	0.0843

Fixed effects: Meanwakebouttimemin ~ ns(date, df = 2) * Intervention + Age + Sex + Mobility + Lawton_T01 + Barthel_T01 + Daily activities (days per week) + Benzodiazepines + Epilepsy
	Value	Std. error	DF	t value	P value
(Intercept)	0.591646	1.2962233	981	0.4564385	0.6482
ns(date, df = 2)1	−1.009352	1.0395716	981	−0.9709306	0.3318
ns(date, df = 2)2	−2.383821	2.0155160	981	−1.1827347	0.2372
Intervention	−2.087531	1.1072613	981	−1.8853103	0.0597
Age	0.006828	0.0144511	31	0.4725066	0.6399
Sex female	−0.107644	0.2639739	31	−0.4077845	0.6862
Mobility with support	0.958049	0.3370689	31	2.8422954	0.0079
Mobility wheelchair	0.011635	0.4670052	31	0.0249150	0.9803
Lawton_T01	0.006192	0.0513241	31	0.1206547	0.9047
Barthel_T01	0.032095	0.0345088	31	0.9300421	0.3595
Daily activities (days per week)	−0.010329	0.0827811	31	−0.1247796	0.9015
Benzodiazepines	−0.238601	0.2463854	31	−0.9684069	0.3403
Epilepsy	0.532300	0.3279498	31	1.6231142	0.1147
ns(date, df = 2)1:Intervention	5.527216	2.1102456	981	2.6192286	0.0089
ns(date, df = 2)2:Intervention	3.344202	2.0313633	981	1.6462847	0.1000