Figure 1.

Overview of data availability and performed analysis. * = Age at onset was determined for incident radiographic osteoarthritis (OA) and was calculated as the age at first diagnosis of radiographic OA. ** = Radiographic OA progression was defined as any progression in the Rotterdam Study (RS) with a ≥1‐degree increment in Kellgren/Lawrence (K/L) score (excluding progression from K/L 0 to K/L 1 or having a total joint replacement [TJR] of one or both joints during the follow‐up period). CHECK = Cohort Hip and Cohort Knee; PROOF = Prevention of Knee Osteoarthritis in Overweight Females; BMI = body mass index; PRS = polygenic risk score; ROC = receiving operating characteristic curve; AUC = area under the ROC; OR = odds ratio. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.42246/abstract.