Figure 3.

Association between OA PRS and risk of OA progression in a meta‐analysis of the Rotterdam Study of 3 cohorts. Any progression was defined by a ≥1‐degree increment of the K/L score (excluding progression from K/L 0 to K/L 1) or having a TJR of one or both joints during the follow‐up period. Early incident OA was defined by a maximum K/L score of 2 for each joint during follow‐up (i.e., K/L 0 or K/L 1 to K/L 2). Incident severe OA was defined by a K/L score of ≥3 or TJR during follow‐up (i.e., K/L 0 or K/L 1 to K/L 3+, or TJR). Progressive severe OA was defined by progression from early OA (K/L 2) to severe OA (K/L 3+) or TJR during follow‐up. See Figure 1 for definitions.