Table 1.

Patients Who Experienced Significant Vision Loss Immediately after Intravitreal Injection with Aflibercept Prefilled Syringes

Patient No.	Age (yrs)	Sex	Laterality	Lens Status	Axial Length (mm)	Glaucoma or Ocular Hypertension?	Receiving Topical Intraocular Pressure-Lowering Drops?	Indication for Intravitreal Injection	Anterior Chamber Paracentesis Needed?	Intraocular Pressure before Procedure (mmHg)	Visual Acuity before Procedure	Visual acuity at Next Office Visit	Case Description
1	90	M	—	Pseudophakic	23.76	Y (glaucoma)	Y	AMD	N	—	—	—	•Received >10 prior aflibercept injections without complication
2	85	F	—	Pseudophakic	Right: 24.32 Left: 24.17	N	N	AMD	N	—	—	—	•Received >10 prior aflibercept injections without complication
3	94	F	—	Pseudophakic	—	N	N	AMD	N	—	—	—	•Received >10 prior aflibercept injections without complication
4	46	M	Right	Phakic	—	N	N	PDR/DME	Y	19	20/60	20/40	•Received 2 prior aflibercept, 1 ranibizumab, and 4 bevacizumab injections without complication •Underwent same-day focal laser treatment •Immediate NLP vision with IOP 64 mmHg
5	70	M	Both	Right: pseudophakic Left: phakic	Right: 23.03 Left: 22.56	Y (ocular hypertension)	Y	AMD	N	Right: 17 Left: 19	Right: 20/50 Left: 20/100	Right: 20/50 Left: 20/40	•Unable to drive home for several hours because of profound loss of vision in both eyes
6	68	F	—	Phakic	—	N	N	AMD	N	—	—	—	•Received >10 prior aflibercept injections without complication
7	82	F	Right	Pseudophakic	—	N	N	AMD	N	15	20/60	20/60	•Received >10 prior aflibercept injections without complication •IOP 40 mmHg immediately after injection brought down to 25 mmHg with topical IOP-lowering drops
8	52	M	Left	Phakic	—	N	N	PDR/DME	Y	13	20/70	20/60	•Received >10 prior aflibercept injections without complication •Immediate light perception vision with IOP of 72 mmHg
9	72	M	Right	Phakic	—	N	N	AMD	N	12	20/50	20/40	•Received >10 prior aflibercept injections without complication •Immediate no light perception vision •Requested switch to vial preparation
10	49	M	Right	Phakic	—	N	N	CNV secondary to CSCR	Y	17	20/80	20/70	•Received >10 prior aflibercept injections without complication •Requested switch to vial preparation
11	65	M	Left	Phakic	—	Y (glaucoma suspect)	N	DME	N	16	20/50	20/40	•Received >10 prior aflibercept injections without complication •Requested medication change; now receiving ranibizumab 0.5 mg
12	74	M	Right	Phakic	—	N	N	AMD	Y	18	20/50	20/40	•Received >10 prior aflibercept injections without complication

AMD = age-related macular degeneration; CNV = choroidal neovascularization; CSCR = central serous chorioretinopathy; DME = diabetic macular edema; F = female; IOP = intraocular pressure; M = male; N = no; PDR = proliferative diabetic retinopathy; Y = yes; – = data is unavailable.