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. 2022 Sep 23;12:915498. doi: 10.3389/fonc.2022.915498

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Copyright © 2022 Qiu, Sang, Chen, Zhou, Wang and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-tumor efficacy of WJR in vitro and in vivo. (A) Cell viability was determined by MTT assay in DLD-1 cells under WJR. (B) Hoechst 33258 staining and (C) flow cytometry assay were used to detect apoptosis of DLD-1 cells. (D, E) Western blot assay was implemented to analyze the expression of apoptosis-related protein Bax and bcl-2. (F) Tumor volume changes in mice treated with different groups. (G) TGI of mice in different groups. (H) H&E of tumor samples, and areas of hyperchromatic nuclei and infiltration of inflammatory cells represent necrosis. NC, control group; LD, low-dose group of WJR; MD, middle-dose group of WJR; HD, high-dose group of WJR; PC, positive group; WJR, Wenzi Jiedu Recipe. H&E, hematoxylin and eosin; TGI, tumor growth inhibition rate. ^*vs. NC, p < 0.05; ^#vs. LD, p < 0.05; ^&vs. MD, p < 0.05.