TABLE 1.
Summary of conjunctional FDR (conjFDR) results for mood instability (MOOD) and each of schizophrenia (SCZ), bipolar disorder (BIP), major depression (DEP), and attention‐deficit hyperactivity disorder (ADHD). Number of joint loci at genome‐wide significance (p < 5 x 10−8), number of joint loci identified at conjFDR <0.05, number of novel loci in each phenotype, number of loci with concordant effect directions in discovery and replication samples, and number of transdiagnostic loci (overlapping between two or more Psych) are presented for each analysis. Psych = psychiatric disorders. There was no replication cohort available for ADHD. The sample sizes of the original Psych GWAS and the number of overlapping loci at genome‐wide significance in the original GWAS (5 × p < 10−8) are provided for comparison.
| Psych | Psych GWAS (n) | Joint loci with MOOD at p < 5 × 10−8 (n) | Joint loci with MOOD at conjFDR <0.05 (n) | Novel loci in MOOD (n) | Novel loci in psych (n) | Joint loci with concordant lead SNPs in replication cohort (n) | Transdiagnostic loci (n) |
|---|---|---|---|---|---|---|---|
| SCZ | 105,318 | 40 | 102 | 71 | 26 | 74 | 41 |
| BIP | 413,463 | 5 | 60 | 42 | 22 | 39 | 35 |
| DEP | 450,619 | 29 | 163 | 140 | 92 | 121 | 38 |
| ADHD | 53,293 | 2 | 28 | 17 | 12 | N/A | 11 |