Fig. 2.

Heatmaps showing the synergistic inhibition of planktonic Candida albicans (SC5314) by (A) toyocamycin combined with fluconazole, (B) Darapladib with fluconazole, and (C) Darapladib with Caspofungin, utilizing the checkerboard microdilution assay (MBIC). Different starting concentrations used for Toyocamycin (8 μg/mL), Darapladib (64 μg/mL), Fluconazole (32 μg/mL) and Caspofungin (2 μg/mL). Directional arrows represent a serial doubling reduction from the stated concentration. Growth was measured at 490 nm OD, and values represent median from three biological replicates with three technical repeats. [Colour figure can be viewed at wileyonlinelibrary.com]