Table 2.
Minimum biofilm killing concentrations (μg/mL) of five different compounds from Tocris 2.0 micro against different Candida species
| Species | SMIC50 (μg/mL) | SMIC80 (μg/mL) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Poly | Dara | KHS | M | TM | FZ | CAS | AmB | Poly | Dara | KHS | M | TM | FZ | CAS | AmB | |
| Candida albicans SC5314 | 16 | 16 | 8 | 64 | >64 | >64 | 0.06 | 0.25 | 32 | 32 | 32 | 64 | >64 | >64 | 0.06 | 2 |
| Candida albicans ATCC 10231 | 32 | 16 | 32 | 64 | >64 | >64 | 0.03 | 1 | 64 | 32 | 64 | 64 | >64 | >64 | 2 | 8 |
| Candida albicans NCPF3153A | 32 | 16 | 32 | 64 | >64 | >64 | 0.5 | 0.25 | 64 | 32 | 32 | >64 | >64 | >64 | >32 | 2 |
| Candida auris NCPF8973 | 64 | 64 | 64 | >64 | >64 | >64 | >64 | 8 | 64 | 64 | >64 | >64 | >64 | >64 | >64 | >64 |
| Candida auris NCPF8978 | 64 | 64 | >64 | >64 | 64 | >64 | >64 | 8 | 64 | 64 | >64 | >64 | >64 | >64 | >64 | 8 |
| Candida glabrata ATCC 2001 | 64 | 8 | 16 | 32 | >64 | >64 | 0.06 | 0.25 | 64 | 8 | 32 | 64 | >64 | >64 | 0.5 | 8 |
| Candida tropicalis BC064 | 64 | 16 | 64 | 64 | >64 | >64 | 0.06 | 2 | >64 | 32 | 64 | 64 | >64 | >64 | 0.5 | 8 |
| Candida haemulonii DSM70624 | 32 | 64 | 64 | 128 | 8 | >64 | 64 | 16 | >64 | 64 | >64 | >64 | >64 | >64 | >64 | >64 |
| Candida parapsilosis NCPF8334 | 32 | 16 | 8 | 16 | >64 | 32 | 0.5 | 0.125 | >64 | 16 | 32 | 32 | >64 | >64 | 1 | 1 |
| Candida krusei NCPF3953 | 32 | 32 | >64 | >64 | 2 | 8 | 32 | 0.5 | 32 | 32 | >64 | >64 | 2 | >64 | >64 | 1 |
Polygodial (Poly), Darapladib (Dara), KHS101 (KHS), M62182 (M), Toyocamycin (TM), Fluconazole (FZ), Caspofungin (CAS), Amphotericin B (AmB). Values represent median from three biological replicates of four technical repeats in each run.