Table 3.
Antifungal effect of toyocamycin alone and in combination with fluconazole, amphotericin B and Caspofungin, on growth of Candida albicans planktonic cells by checkerboard microdilution assay
| Strain | Drug | PMIC of drug alone (μg/mL) | PMIC of drug in combination (μg/mL) | FIC | FICI | Outcome |
|---|---|---|---|---|---|---|
| SC5314 | Toyocamycin | 1 | 0.25 | 0.25 | 0.31 | Synergy |
| Fluconazole | 32 | 2 | 0.06 | |||
| Toyocamycin | 1 | 1 | 1 | 1.06 | Indifference | |
| Caspofungin | 0.5 | 0.03 | 0.06 | |||
| Toyocamycin | 1 | 2 | 2 | 2.12 | Indifference | |
| Amphotericin B | 0.5 | 0.06 | 0.12 | |||
| BC023 | Toyocamycin | 0.5 | 0.125 | 0.25 | 0.37 | Synergy |
| Fluconazole | 32 | 4 | 0.125 | |||
| Toyocamycin | 0.5 | 0.25 | 0.5 | 1 | Indifference | |
| Caspofungin | 2 | 1 | 0.5 | |||
| Toyocamycin | 0.5 | 1 | 2 | 2.06 | Indifference | |
| Amphotericin B | 0.5 | 0.03 | 0.06 | |||
| BC146 | Toyocamycin | 0.5 | 0.125 | 0.25 | 0.31 | Synergy |
| Fluconazole | 32 | 2 | 0.06 | |||
| Toyocamycin | 0.5 | 0.5 | 1 | 1.03 | Indifference | |
| Caspofungin | 1 | 0.03 | 0.03 | |||
| Toyocamycin | 0.5 | 0.25 | 0.5 | 1 | Indifference | |
| Amphotericin B | 0.5 | 0.25 | 0.5 |