Table 4.
Antifungal effect of Darapladib alone and in combination with fluconazole, amphotericin B and Caspofungin, on growth of Candida albicans planktonic cells by checkerboard microdilution assay
| Strain | Drug | PMIC of drug alone (μg/mL) | PMIC of drug in combination (μg/mL) | FIC | FICI | Outcome |
|---|---|---|---|---|---|---|
| SC5314 | Darapladib | 8 | 1 | 0.125 | 0.14 | Synergy |
| Fluconazole | 32 | 0.5 | 0.015 | |||
| Darapladib | 8 | 2 | 0.25 | 0.37 | Synergy | |
| Caspofungin | 0.25 | 0.03 | 0.12 | |||
| Darapladib | 8 | 2 | 0.25 | 0.5 | Indifference | |
| Amphotericin B | 0.25 | 0.0625 | 0.25 | |||
| BC023 | Darapladib | 8 | 2 | 0.25 | 0.26 | Synergy |
| Fluconazole | 32 | 0.5 | 0.015 | |||
| Darapladib | 8 | 2 | 0.25 | 0.31 | Synergy | |
| Caspofungin | 0.5 | 0.03 | 0.06 | |||
| Darapladib | 8 | 4 | 0.5 | 0.62 | Indifference | |
| Amphotericin B | 0.25 | 0.03 | 0.12 | |||
| BC146 | Darapladib | 0.5 | 0.125 | 0.25 | 0.31 | Synergy |
| Fluconazole | 32 | 2 | 0.06 | |||
| Darapladib | 8 | 2 | 0.25 | 0.31 | Synergy | |
| Caspofungin | 0.5 | 0.03 | 0.06 | |||
| Darapladib | 8 | 4 | 0.5 | 0.74 | Indifference | |
| Amphotericin B | 0.125 | 0.03 | 0.24 |