FIGURE 5.

Selectivity test of the N‐terminally truncated GLP‐2 variants on human GLP‐1R and human GIPR. COS‐7 cells were transiently transfected with either human GLP‐2R, human GLP‐1R or human GIPR, and the agonistic and antagonistic profiles of the N‐terminally truncated GLP‐2 variants were examined in cAMP accumulation. (a) Agonistic and (b) antagonistic activities of the N‐terminally truncated GLP‐2 variants on human GLP‐2R, (c) agonistic and (d) antagonistic activities of the N‐terminally truncated GLP‐2 variants on the human GLP‐1R and (e) agonistic and (f) antagonistic activites of the N‐terminally truncated GLP‐2 variants on the human GIPR. Data are shown as mean ± SEM, from n = 3 independent experiments carried out in duplicate