TABLE 2.
Differences in treatment responses to duloxetine and placebo treatments and calculated analgesic effects presented as absolute and percentage differences
| Duloxetine | Placebo | p‐value | ||||
|---|---|---|---|---|---|---|
| Before | After | Before | After | Time | Drug | |
| Time effects of treatments | ||||||
| BPI worst pain | 5.56 (2.29) | 3.08 (2.71) | 4.92 (2.55) | 3.96 (2.48) | p < 0.001 | 1.000 |
| BPI average pain | 4.42 (1.95) | 2.42 (2.02) | 4.00 (2.23) | 3.25 (2.09) | p < 0.001 | 0.447 |
| WOMAC pain | 8.56 (2.97) | 6.44 (3.79) | 8.29 (3.58) | 6.83 (3.82) | p = 0.002 | 0.890 |
| WOMAC total | 36.56 (13.91) | 28.28 (19.58) | 36.58 (18.01) | 30.00 (16.68) | p < 0.001 | 0.994 |
| Mean difference | p‐value | |||
|---|---|---|---|---|
| Absolute differences comparing treatments | ||||
| BPI Worst pain | 2.48 (3.38) | 1.28 (2.49) | 1.20 (4.74) | 0.218 |
| BPI average pain | 1.96 (2.85) | 0.96 (2.41) | 1.00 (4.20) | 0.246 |
| WOMAC pain | 2.12 (4.14) | 1.84 (4.12) | 0.28 (6.255) | 0.825 |
| WOMAC total | 8.28 (18.96) | 8.48 (14.91) | 0.20 (27.93) | 0.972 |
| Mean difference | p‐value | |||
|---|---|---|---|---|
| Percentage differences comparing treatments | ||||
| BPI Worst pain | 33.69 (59.51) | 16.98 (52.31) | 15.37 (78.86) | 0.340 |
| BPI Average pain | 36.84 (65.75) | 2.08 (111.95) | 34.77 (123.51) | 0.266 |
| WOMAC pain | 21.02 (44.31) | 21.30 (46.95) | 0.28 (58.96) | 0.981 |
| WOMAC total | 20.02 (48.21) | 23.29 (35.34) | 3.27 (58.66) | 0.783 |
Abbreviations: BPI, Brief Pain Inventory; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.