FIGURE 7.

Nonobese Acod1^−/− mice have altered energy substrate utilization. Three‐month‐old chow‐diet‐fed weight‐matched wild‐type (WT) and Acod1 ^−/− mice analyzed by (A) CLAMS for food intake, (B) energy expenditure, and (C) fat and glucose oxidation. (D) Enriched pathways in chow‐fed WT and Acod1 ^−/− mice (GSEA; p _adj < 0.05). (E) Heat map of differentially expressed genes related to fatty acid (FA) synthesis. N = 5 per group. *p < 0.05. LBM, lean body mass; ND, normal diet [Color figure can be viewed at wileyonlinelibrary.com]