FIGURE 2.

Recommended NTRK gene fusion testing algorithm for colorectal cancer. (+)/(–): Presence/absence of NTRK gene fusions. *Accessible: Testing platform is available and affordable. †Standard treatment: If pMMR/MSS, 1L/2L‐chemotherapy and/or monoclonal antibody, 3L/4L: regorafenib or TAS‐102; if dMMR/MSI‐high: 1L‐pembrolizumab or chemotherapy with or without monoclonal antibody, 2L/3L: chemotherapy and/or monoclonal antibody or pembrolizumab. Abbreviations: BRAF, v‐raf murine sarcoma viral oncogene homolog B; 1L/2L/3L/4L, first/second/third/fourth line; KRAS, Kirsten rat sarcoma viral oncogene homolog; MLH1, MutL Homolog 1; MSI, microsatellite instability; MSS, microsatellite stable; NGS, next‐generation sequencing; NRAS, neuroblastoma RAS viral oncogene homolog; NTRK, neurotrophic tyrosine receptor kinase; p/d/MMR, proficient‐/deficient‐/mismatch repair; WT, wild type