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. Author manuscript; available in PMC: 2022 Oct 7.
Published in final edited form as: Clin Pharmacol Ther. 2021 Dec 8;111(5):1022–1035. doi: 10.1002/cpt.2482

Table 1.

For varying extraction ratios, the values to be multiplied by hepatic blood flow to obtain clearances for arterial, parallel tube venous and well-stirred venous models

Extraction Ratio Arterial CL CartCveinCart Parallel Tube Venous CL CartCveinCartCveinlnCartCvein Well-Stirred Venous CL CartCveinCvein
0.05 0.050 0.051 0.053
0.10 0.100 0.105 0.111
0.30 0.300 0.357 0.429
0.50 0.500 0.693 1.000
0.632 0.632 1.000 1.72
0.70 0.700 1.20 2.33
0.90 0.900 2.30 9.00
0.95 0.950 3.00 19.0