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SIRT6 deacetylates YAP and TAZ and alters the TEAD protein complex composition in HSCs. (A–C) YAP, TAZ, and SMAD3 acetylation analysis in LX‐2 cells transfected with either GFP, WT Sirt6, or mutant Sirt6 (H133Y) in the presence of 5 ng/ml TGF‐β1. (D) Co‐IP analysis of interactions between TEAD1 and YAP, TAZ, or VGLL4 in LX‐2 cells transfected with either vector control or SIRT6 plasmids in the presence of 5 ng/ml TGF‐β1.
