Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A working model for the role of SIRT6 in the regulation of YAP/TAZ and hepatic fibrogenesis.When SIRT6 is sufficiently active, YAP and TAZ are suppressed in HSCs. This promotes a quiescent state of HSCs. Under pathogenic conditions, SIRT6 activity is markedly reduced, and this leads to highly acetylated YAP and TAZ that promote HSC activation and fibrogenesis.
