TABLE 1.
Hemogram before treatment, processed blood volume (BV) and buffy coat (BC) volume, BC composition, collection efficiency (CE), and throughput (CT)
| Integrated | Multistep nonintegrated | Integrated | Multistep nonintegrated | |
|---|---|---|---|---|
| Mean (SD) | Median (range) | |||
| Hemogram before treatment | ||||
| WBC G/L | 7.18 (2.76) | 7.10 (2.60) | 6.66 (2.11‐13.23) | 6.92 (1.57‐12.19) |
| HCT% | 35.98 (4.55) †† | 37.19 (5.02) †† | 36.75 (28.00‐46.90) | 37.20 (29.00‐46.90) |
| Total BV (L) | 4.82 (0.67) | 4.82 (0.67) | 4.79 (3.617‐5.95) | 4.79 (3.617‐5.95) |
| BV volume and BC volume | ||||
| Processed BV (L) | 1.53 (0.02) | 2.87 (0.55) | 1.54 (1.50‐1.57) | 2.85 (1.56‐4.42) |
| BC volume (mL) | 131.50 (14.89) a , b | 100.00 (‐) ** | 129.00 (110.00‐181.00) b | 100.00 (‐) |
| Number of cells collected | ||||
| WBC × 109 | 3.37 (1.91) | 3.89 (2.38) | 2.63 (1.42‐11.50) | 3.48 (1.52‐10.50) |
| WBC × 107/kg | 4.69 (2.45) | 5.27 (2.95) | 3.97 (2.09‐13.69) | 4.46 (2.37‐14.90) |
| BC composition (imputed values for lymphocytes and monocytes) | ||||
| HCT% | 3.36 (1.52) | 2.91 (1.09) | 2.75 (1.80‐8.30) | 2.80 (1.30‐5.70) |
| WBC G/L | 26.26 (16.10) ** | 38.90 (23.80) ** | 20.40 (8.47‐95.39) | 34.72 (15.20‐104.45) |
| Lym G/L b | 10.42 (6.13)* | 17.43 (8.54)† | 7.96 (4.48‐22.35) | 17.28 (7.28‐36.65) |
| Mono G/L b | 6.76 (3.26) | 8.97 (3.60) | 5.44 (3.56‐13.84) | 8.68 (4.23‐17.58) |
| Lym % b | 45.56 (18.53) | 50.74 (15.66) | 43.10 (16.10‐69.20) | 50.00 (23.20‐71.00) |
| Mono % b | 28.45 (5.88)† | 26.98 (8.36)† | 28.00 (19.40‐40.50) | 27.70 (13.80‐44.80) |
| Purity b | 74.01 (17.76) | 77.72 (18.14) | 69.70 (43.00‐96.00) | 81.40 (37.00‐98.70) |
| Collection efficiency (CE) and throughput (CT) | ||||
| CE (%) | 34.23 (19.57) ** | 21.03 (11.82) ** | 28.78 (8.98‐105.31) | 17.98 (7.81‐64.00) |
| CT (mL/min) | 7.79 (3.63) | 7.84 (3.82) | 7.59 (2.98‐20.40) | 7.82 (2.82‐18.03) |
Abbreviations: BC, Buffy coat; BV, blood volume; CE, collection efficiency; CT, collection throughput; HCT, hematocrit; Lym, lymphocytes; Mono, monocytes; SD, standard deviation; WBC, white blood cell.
*
P = .0066.
**
P = .0088.
†
P = .0084.
††
P < .0001.
a
Prefilled with 50 mL saline in the bag.
b
Treatment pairs with missing data for MNC counts were excluded (included pairs = 11).