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Proposed pathophysiological model of RLS. BID, brain iron deficiency; C‐S‐T‐C circuits, cortico‐striatal‐thalamic‐cortical circuits; PLMS, periodic leg movements in sleep (Ferré, García‐Borreguero, Allen, & Earley, The Neuroscientist, New Insights into the neurobiology of restless legs syndrome. Vol 25(2) 113‐125, copyright © 2019 by The Author(s). Reprinted by permission of SAGE Publications)
