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. 2022 Sep 29;14(1):2127444. doi: 10.1080/19490976.2022.2127444

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — HDAC1 and HDAC5 control Enterobacteria colonization in ileal mucosa of CD patients. The HDAC1/HDAC5 expression balance is crucial in the control of the interaction between Enterobacteria and intestinal epithelial cells in ileal mucosa of CD patients, a reduced HDAC1 expression associated with an increased expression of HDAC5 being conditions favoring Enterobacteria and AIEC gut colonization. Consumption of a high-fat diet leads to alterations of global H3 acetylation level and creates a specific micro-environment that allows AIEC bacteria to reach intestinal epithelium. In this environment, AIEC bacteria are able to imbalance HDAC1 and HDAC5 expressions to their advantage to colonize the gut mucosa. Targeting HDAC5 could represent an interesting approach to prevent AIEC colonization in CD patients. Ac: acetylation.