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. 2021 Nov 23;17(10):1143–1158. doi: 10.1080/15592294.2021.1997404

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Manhattan plots showing meta-analysis of EWAS of cerebral white matter (2A), total grey matter (2B), and whole-brain volume (2 C), across the 2 concurrent sets ^(Nset 1^{=331; N}set 2^{=234; N}total⁼⁵⁶⁵⁾. The black line defines the threshold for epigenome-wide significance (p ≤ 6.5x10⁻⁸) and the dotted line defines p ≤ 1x10⁻⁵. CpGs that met a significance of p ≤ 1x10⁻⁵ are labelled on the graph.