Table 1.
In vitro neutralization potency of CT-P63 against live viruses and pseudoviruses.
| IC50 (ng/mL) | Fold change (reduction) | |
|---|---|---|
| Live viruses | ||
| Wild-type (B.1) | 50.50 | N/A |
| Omicron (B.1.1.529.1/BA.1) | 96.48 | 1.91 |
| Omicron (B.1.1.529.2/BA.2) | 88.67 | 1.76 |
| Omicron (BA.2.12.1) | 46.95 | 0.93 |
| Delta (B.1.617.2) | 18.88 | 0.37 |
| Gamma (P.1) | 7.21 | 0.14 |
| Beta (B.1.351) | 20.58 | 0.41 |
| Kappa (B.1.617.1) | 25.84 | 0.51 |
| Alpha (B.1.1.7) | 22.46 | 0.44 |
| Epsilon (B.1.427) | 58.48 | 1.16 |
| Epsilon (B.1.429) | 34.28 | 0.68 |
| Eta (B.1.525) | 14.53 | 0.29 |
| Iota (B.1.526) | 44.44 | 0.88 |
| Zeta (P.2) | 31.79 | 0.63 |
| Pseudoviruses | ||
| D614G | 4.81 | N/A |
| Omicron (B.1.1.529.1/BA.1) | 22.29 | 4.63 |
| Omicron (B.1.1.529.2/BA.2) | 9.45 | 1.96 |
| Omicron (BA.2.12.1) | 5.46 | 1.14 |
| Omicron (BA.3) | 12.0 | 2.49 |
| Delta (L452R/T478K/P681R) | 5.32 | 1.11 |
| Gamma (P.1) | 1.71 | 0.36 |
| Beta (B.1.351) | 3.27 | 0.68 |
| Lambda (C.37) | 18.69 | 3.89 |
| Mu (B.1.621) | 12.18 | 2.53 |
| Kappa (L452R/E484Q/P681R) | 8.26 | 1.72 |
| Alpha (B.1.1.7) | 4.85 | 1.01 |
| Epsilon (B.1.427) | 14.10 | 2.93 |
| Epsilon (B.1.429) | 5.86 | 1.22 |
| Eta (B.1.525) | 5.57 | 1.16 |
| Iota (B.1.526) | 3.53 | 0.73 |
| Zeta (P.2) | 2.16 | 0.45 |
Notes: Fold changes were calculated relative to wild-type live virus or D614G pseudovirus for live viruses and pseudoviruses, respectively.
IC50, half-maximal inhibitory concentration; N/A, not applicable.