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. 2022 Oct 1;11(1):2124666. doi: 10.1080/2162402X.2022.2124666

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Figure 3. — Antitumor activity and increase in overall survival from treatment with αTIGIT and bintrafusp alfa is dependent on CD4⁺ and CD8⁺ T cells. (a) Graphical representation of experimental design. (b) MC38-CEA tumor growth curves and (c) survival proportions of CEA.Tg animals treated with αTIGIT + bintrafusp alfa (red line; n = 11), αTIGIT + bintrafusp alfa depleted of CD4⁺ T cells (blue line; n = 11), αTIGIT + bintrafusp alfa depleted of CD8⁺ T cells (green line; n = 12), αTIGIT + bintrafusp alfa depleted of NK cells (purple line; n = 11), αTIGIT + bintrafusp alfa depleted of CD4⁺, CD8⁺ and NK cells (gray line; n = 11), and untreated animals (black line; n = 11). (d) Median survival of each treatment group. (e) Individual animal tumor growth rates of each treatment group. Numbers at the bottom right of tumor growth rate plots indicate tumor-free mice. * = p < .05, ** = p < .01, *** = p < .005, *** = p < .0001.