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. Author manuscript; available in PMC: 2023 Sep 29.
Published in final edited form as: Cell. 2022 Sep 29;185(20):3705–3719.e14. doi: 10.1016/j.cell.2022.09.007

Figure 4. Meropenem treatment results in increased localization of BT to the colonic mucosa in allogeneic mice.

Figure 4.

(A) Experimental schema to analyzed paired fecal and mucosal microbiome by 16S rRNA sequencing. Paired stool and mucus were collected in distal colon. (B) PCoA of stool and mucus in distal colon from normal B6D2F1 mice. (C) Ratio of relative abundance of Bacteroidia/Clostridia in stool and mucus from normal B6D2F1 mice. (D) PCoA of stool and mucus in distal colon from allogeneic mice (left) and meropenem-treated allogeneic mice (right). Numbers shown in each PCoA depict samples collected from the same individual mouse. (E) Beta diversity distances within individual mouse. (F) Ratio of relative abundance of Bacteroidia/Clostridia in stool and mucus from allogeneic mice treated or untreated with meropenem. (B - F) Data from one representative experiment are shown.