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Coverage of estimated CSF Css,avg over ALK inhibition targets in patients receiving 100 mg QD lorlatinib dosing and a confirmed L1196M (a) or G1202R (b) mutation. The green line shows the unbound target concentrations for L1196M (21.08 ng/mL) inhibition. The red line shows the unbound target concentrations for G1202R (67.06 ng/mL) inhibition. 29 ALK, anaplastic lymphoma kinase; CSF, cerebrospinal fluid; Css,avg, average steady‐state plasma concentration; QD, once daily.
