Table 3.
Differences in delta β values for CpG sites differing between current-current smokers (n = 112) and all non-smoking categories (n = 309) at FDR < 0.05.
| CpG site | Location (hg19) | Gene symbol | Difference in delta β± SE | FDR | Cohort-specific delta β direction (FHS, ARIC)* |
|---|---|---|---|---|---|
| cg05575921 | chr5:373378 | AHRR | −0.0407 ± 0.004 | 4.80E-18 | – |
| cg23576855 | chr5:373299 | AHRR | −0.0327 ± 0.0047 | 7.52E-07 | – |
| cg26703534 | chr5:377358 | AHRR | −0.0212 ± 0.0031 | 1.42E-06 | – |
| cg14817490 | chr5:392920 | AHRR | −0.0195 ± 0.0034 | 0.001 | – |
| cg03636183 | chr19:17000585 | F2RL3 | −0.0188 ± 0.0034 | 0.002 | – |
| cg21566642 | chr2:233284661 | – | −0.0187 ± 0.0035 | 0.006 | – |
| cg16145216 | chr1:42385662 | HIVEP3 | 0.0134 ± 0.0026 | 0.015 | ++ |
| cg24639862 | chr11:85359006 | TMEM126A | 0.0009 ± 0.0002 | 0.030 | ++ |
| cg14339116 | chr9:77062053 | – | 0.0059 ± 0.0012 | 0.044 | ++ |
* + indicates a positive cohort-specific delta β value, – indicates a negative cohort-specific delta β value.
Abbreviations: CpG, cytosine-phosphate-guanine; SE, standard error; FDR, false discovery rate; FHS, Framingham Heart Study; ARIC, Atherosclerosis Risk in the Community; AHRR, aryl hydrocarbon receptor repressor; F2RL3, coagulation factor II receptor-like 3; HIVEP3, human immunodeficiency virus type I enhancer-binding protein 3; TMEM126A, transmembrane protein 126A