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. 2022 Jun 20;29(9):2810–2822. doi: 10.1111/ene.15428

TABLE 3.

Correlation between neurofilament light chain values and clinical scales in patients with Guillain–Barré syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy at different time points

GBS CIDP MMN
CSF CSF CSF
Spearman’s r GBSds 0 m GBSds 3 m GBSds 6 m GBSds 12 m Spearman’s r INCAT 3 m INCAT 18 m INCAT 8–10 y Spearman’s r INCAT‐arm 0 m
r 0.43 0.51 0.48 0.46 r 0.48 0.69 0.7 r 0.54
p value 0.03 0.01 0.02 0.03 p value 0.04 0.001 0.01 p value 0.21
p value summary * * * * p value summary * ** * p value summary ns
Plasma Plasma Plasma
Spearman’s r GBSds 0 m GBSds 3 m GBSds 6 m GBSds 12 m Spearman’s r INCAT 3 m INCAT 18 m INCAT 8–10 y Spearman’s r INCAT‐arm 0 m
r 0.31 0.48 0.46 0.46 r 0.39 0.57 0.28 r 0.81
p value 0.16 0.03 0.03 0.04 p value 0.09 0.01 0.39 p value 0.01
p value summary ns * * * p value summary ns * ns p value summary *

Abbreviations: 0 m, the time of diagnostic lumbar puncture; 3 m, 3 months after symptom onset; 6 m, 6 months after symptom onset, etc.; CIDP, chronic inflammatory demyelinating polyneuropathy; CSF, cerebrospinal fluid; GBS, Guillain–Barré syndrome; GBSds, GBS disability scale; INCAT, Inflammatory Neuropathy Cause and Treatment disability score; m, months; MMN, multifocal motor neuropathy; ns, not significant; r, Spearman'`s correlation coefficient; y, year.

* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.