TABLE 4.

Association between neurofilament light chain levels and outcome in patients with Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy

GBS
Simple logistic regression						Multiple logistic regression
CSF						CSF
Outcome1	Variable	OR	CI 95%	p value	p value summary	Outcome1	Variable	OR	CI 95%	p value	p value summary
6 months	NfL2	15.8	1.9–351.4	0.02	*	6 months	Age	0.9	0.8–1.1	0.9	ns
							NfL2	22.6	1.8–917.4	0.03	*
12 months	NfL2	31.5	3.2–817.9	0.009	**	12 months	Age	1.03	0.9–1.2	0.57	ns
							NfL2	20.8	1.7–713.5	0.03	*

PLASMA						PLASMA
Outcome1	Variable	OR	CI 95%	p value	p value summary	Outcome1	Variable	OR	CI 95%	p value	p value summary
6 months	NfL2	31.5	3.3–817.9	0.009	**	6 months	Age	1.1	0.9–1.3	0.39	ns
							NfL2	31.2	2.02–1357	0.02	*
12 months	NfL2	13.8	1.6–311.5	0.03	*	12 months	Age	1.01	0.8–1.2	0.9	ns
							NfL2	59.5	2.4–9756	0.03	*

CIDP
Simple logistic regression						Multiple logistic regression
CSF						CSF
Outcome3	Variable	OR	CI 95%	p value	p value summary	Outcome3	Variable	OR	CI 95%	p value	p value summary
6 months	NfL4	8.2	1.2–83.4	0.04	*	6 months	Age	1.05	0.95–1.18	0.40	ns
							NfL4	3.7	0.30–59.2	0.31	ns
12 months	NfL4	8.0	1.4–81.2	0.04	*	12 months	Age	1.03	0.94–1.14	0.50	ns
							NfL4	4.73	0.42–77.53	0.22	ns
18 months	NfL4	18.0	2.1–425.3	0.02	*	18 months	Age	1.10	0.98–1.28	0.14	ns
							NfL4	5.27	0.33–151.5	0.25	ns
24 months	NfL4	15.0	1.6–359.4	0.03	*	24 months	Age	1.01	0.91–1.11	0.89	ns
							NfL4	10.03	0.66–376.2	0.13	ns

PLASMA						PLASMA
Outcome3	Variable	OR	CI 95%	p value	p value summary	Outcome3	Variable	OR	CI 95%	p value	p value summary
6 months	NfL4	3.0	0.5–22.1	0.25	ns	6 months	Age	1.09	0.99–1.22	0.11	ns
							NfL4	0.84	0.06–9.39	0.89	ns
12 months	NfL4	2.9	0.4–21.7	0.26	ns	12 months	Age	1.07	0.98–1.19	0.19	ns
							NfL4	0.97	0.07–11.64	0.98	ns
18 months	NfL4	18.7	2.1–439.3	0.02	*	18 months	Age	1.15	0.99–1.52	0.13	ns
							NfL4	1.13	1.02–1.38	0.07	ns
24 months	NfL4	16.7	1.8–397.4	0.02	*	24 months	Age	1.01	0.91–1.11	0.89	ns
							NfL4	15.1	1.15–540.2	0.06	ns

Note: ¹Binary outcome favourable vs. unfavourable (unfavourable outcome = inability to run, GBSds 2 points or higher); ²binary variable low vs. high (based on median GBS cohort CSF NfL or plasma NfL); ³binary outcome favourable vs. unfavourable (unfavourable = INCAT 3 points or higher); ⁴binary variable low vs. high (based on median CIDP cohort CSF NfL or plasma NfL); age in years as a continuous variable.

Abbreviations: CI 95%, 95% confidence interval; CIDP, chronic inflammatory demyelinating polyneuropathy; CSF, cerebrospinal fluid; GBS, Guillain–Barré syndrome; GBSds, GBS disability scale; INCAT, Inflammatory Neuropathy Cause and Treatment disability score; NfL, neurofilamaent light chain; ns, not significant; OR, odds ratio.

^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001.