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. 2022 Jul 21;41(9):2221–2239. doi: 10.1002/etc.5403

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Published 2022. This article is a U.S. Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Summation of concentrations of Method 1 pharmaceuticals detected in Great Lakes tributary sampling sites, October 2017–September 2018. (A) Bar plot of concentrations grouped by site and separated based on the relative mean daily flow conditions present on sample collection dates. (B) Boxplots of summations of Method 1 pharmaceutical concentrations normalized by mean sample concentrations from individual sites. Mean normalized concentrations showed a significant difference (p < 0.05) between low‐flow and increased‐flow samples, according to Welch's two‐sample t test. Boxes depict the first through third quartiles; dark line, median; whiskers, data within 1.5 times the interquartile range. HC = Harbor Canal; N Br = North Branch; M Br = Middle Branch; S Br = South Branch; US = upstream; DS = downstream.