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. 2022 Jul 21;41(9):2221–2239. doi: 10.1002/etc.5403

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Published 2022. This article is a U.S. Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Pharmaceutical detections and exceedances of incremental hazard quotient thresholds for ToxCast exposure–activity ratios (left) and ECOTOX‐derived toxicity quotients (right), organized by sampling site. The number of pharmaceuticals detected at each site is represented by the combination of stacked bars (e.g., 60 pharmaceuticals were detected at Clinton). The number of pharmaceuticals monitored at each site is indicated by the border color of the respective bar (e.g., 257 pharmaceuticals were monitored at Clinton). The number of samples collected from each of the 44 Great Lakes tributary sampling sites, October 2017–September 2018, is listed following the site name. EAR = exposure–activity ratio; TQ = toxicity quotient; HWY = highway; HC = Harbor Canal; N Br = North Branch; M Br = Middle Branch; S Br = South Branch; US = upstream; DS = downstream.