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. 2022 Jul 21;41(9):2221–2239. doi: 10.1002/etc.5403

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Published 2022. This article is a U.S. Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Pharmaceutical hazard quotients by site in the Great Lakes Basin from water samples collected in 44 Great Lakes tributary sampling sites, October 2017–September 2018. Sum of maximum ToxCast exposure–activity ratio values for all ToxCast assays (left) and maximum ECOTOX‐derived toxicity quotients for each pharmaceutical (right). The number of additional pharmaceuticals represented by each respective alternative benchmark is provided in parentheses next to “Others” in the key. EAR = exposure–activity ratio; TQ = toxicity quotient; HWY = highway; HC = Harbor Canal; N Br = North Branch; M Br = Middle Branch; S Br = South Branch; US = upstream; DS = downstream.