Table 2.

High‐priority pharmaceuticals, as determined by exceedance of the ToxCast exposure–activity ratio threshold of 10⁻³ or the ECOTOX toxicity quotient threshold of 0.1 at 10% or more of the sites from surface water monitoring results in Great Lakes tributaries, October 2017–September 2018

			Exceedances by site
CAS	Chemical	Class	ToxCast EAR	ECOTOX TQ	Sites monitored
58‐08‐2	Caffeine	Stimulant	38	38	44
54‐11‐5	Nicotine	Stimulant	31	13	44
298‐46‐4	Carbamazepine	Anticonvulsant	0	33	44
723‐46‐6	Sulfamethoxazole	Antibiotic	–	33	44
93413‐69‐5	Venlafaxine	Antidepressant	–	33	44
103‐90‐2	Acetaminophen	Analgesic	0	31	44
51384‐51‐1	Metoprolol	Cardiovascular care	0	29	44
148‐79‐8	Thiabendazole	Anthelmintic	6	0	44
18559‐94‐9	Albuterol	Asthma relief	5	–	44
25812‐30‐0	Gemfibrozil	Anticholesteremic	0	5	37

CAS = Chemical Abstracts Service; TQ = toxicity quotient; EAR = exposure–activity ratio.