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. 2022 Sep 14;50(5):134. doi: 10.3892/ijmm.2022.5190

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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CAPE blocks the levels of IL-1β-induced inflammatory mediators in human chondrocytes. (A) The mRNA expression of COX-2 and iNOS was detected using reverse transcription-quantitative PCR. The protein expression of COX2 and iNOS was (B) detected using western blotting and (C) quantified. (D) The production of nitric oxide was detected via the Griess reaction. (E) The production of prostaglandin E2 was detected using ELISA. ^*P<0.05, ^**P<0.01, ^***P<0.001 and ^****P<0.0001. CAPE, caffeic acid phenethyl ester; COX-2, cyclooxygenase-2; iNOS, inducible nitric oxide synthase.