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. 2022 Sep 16;50(5):135. doi: 10.3892/ijmm.2022.5191

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Copyright: © Kyriazis et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Graphical illustration depicting distinct pathways that induces mitochondrial biogenesis via PGC-1α activation. The image was created using the Smart servier medical art website; smart.servier.com. PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator 1α; AMP, adenosine monophosphate; ATP, adenosine triphosphate; SIRT1, sirtuin 1; AMPK, AMP-activated protein kinase; CREB, cAMP response element-binding protein; PPARs, peroxisome proliferator-activated receptors; NRF, nuclear respiratory factor; TFAM, mitochondrial transcription factor A; mtDNA, mitochondrial DNA.