Table 2.
Circadian gene methylation differences between current night shift and day shift workers.
| Illumina ID | Chromosome | Position | Gene | Gene Groupa | Relation to CpG Islandb | Meanc methylation in day workers (SD) | Meanc methylation in night shift workers (SD) | Adjustedd mean difference (95% CI) | q-valuee |
|---|---|---|---|---|---|---|---|---|---|
| cg14718583 | 22 | 38,725,060 | CSNK1E | 5ʹUTR | Open sea | 87.72 (1.84) | 88.57 (1.57) | 1.69 (0.87, 2.52) | 0.18 |
| cg20667664 | 17 | 38,254,448 | NR1D1 | Body | North Shore | 78.97 (1.65) | 78.29 (1.51) | −1.53 (−2.38, −0.67) | 0.52 |
| cg12596843 | 11 | 45,864,825 | CRY2 | - | North Shelf | 12.73 (1.28) | 12.41 (0.84) | −0.89 (−1.43, −0.35) | 0.67 |
| cg23929615 | 22 | 38,794,688 | CSNK1E | TSS200 | Island | 52.41 (2.28) | 51.06 (2.09) | −2.07 (−3.34, −0.79) | 0.67 |
| cg10472395 | 15 | 61,070,548 | RORA | Body | Open Sea | 82.50 (1.38) | 81.96 (1.45) | −1.09 (−1.80, −0.39) | 0.69 |
| cg10976861 | 2 | 239,149,937 | PER2 | TSS1500 | South Shore | 33.86 (2.11) | 32.64 (1.61) | −1.58 (−2.60, −0.55) | 0.69 |
| cg26113056 | 15 | 61,521,643 | RORA | TSS200 | Island | 8.97 (1.56) | 8.57 (1.21) | −1.03 (−1.71, −0.35) | 0.69 |
| cg23965982 | 15 | 61,055,848 | RORA | Body | Open Sea | 83.96 (1.91) | 83.44 (1.41) | −1.23 (−2.07, −0.38) | 0.78 |
| cg16774421 | 12 | 27,481,875 | ARNTL2 | - | North Shelf | 92.20 (1.33) | 91.85 (1.14) | −0.91 (−1.54, −0.27) | 0.78 |
| cg13184823 | 4 | 187,476,599 | MTNR1A | TSS200 | Island | 38.96 (8.07) | 41.24 (6.26) | 5.42 (1.59, 9.25) | 0.78 |
a. Functional region of gene as indicated in Illumina annotation.
b. Position relative to CpG Island as indicated in Illumina annotation.
c. Unadjusted mean.
d. All analyses adjusted for age, income, part/full-time status, occupational exposures to radiation and disinfectants, and leukocyte cell profile. Day workers are the referent category.
e. Q-values represent p-values adjusted for multiple testing using the FDR method.