Table 3.

Circadian gene methylation differences between workers with ≥10 years of night shift work duration and workers with <10 years.

Illumina ID	Chromosome	Position	Gene	Gene Groupa	Relation to CpG Islandb	Meanc methylation in <10 years workers (SD)	Meanc methylation in ≥10 years workers (SD)	Adjustedd mean difference (95% CI)	q-valuee
cg20667664	17	38,254,448	NR1D1	Body	North Shore	79.13 (1.73)	78.15 (1.33)	−1.60 (−2.33 – 0.87)	0.08
cg22405816	9	118,135,937	DEC1	5ʹUTR	Open Sea	84.68 (2.47)	83.25 (2.65)	−1.84 (−2.87,0.81)	0.32
cg00436663	22	38,793,933	CSNK1E	Body	Island	7.54 (0.93)	7.07 (0.85)	−0.74 (−1.18, – 0.31)	0.32
cg24219929	15	60,884,748	RORA	Body	Island	9.83 (7.03)	6.37 (3.38)	−4.81 (−7.63, – 1.98)	0.32
cg18204040	12	26,279,190	BHLHE41	TSS1500	Island	10.69 (0.72)	10.20 (0.69)	−0.56 (−0.90, −0.22)	0.32
cg06233947	16	58,230,251	CSNK2A2	Body	North Shore	92.20 (1.17)	91.32 (1.49)	−1.13 (−1.81, – 0.44)	0.32
cg26724232	15	60,885,912	RORA	Body	South Shore	81.46 (3.30)	83.61 (2.65)	2.24 (0.85, 3.63)	0.32
cg09473510	4	187,476,573	MTNR1A	TSS200	Island	19.92 (8.21)	23.99 (7.45)	5.19 (1.97, 8.41)	0.32
cg13154331	22	38,795,868	CSNK1E	TSS1500	South Shore	70.52 (2.44)	71.55 (2.17)	1.52 (0.57, 2.48)	0.32
cg07250429	15	61,051,202	RORA	Body	Open Sea	84.76 (1.22)	83.98 (1.57)	−1.03 (−1.68, –0.38)	0.32

a. Functional region of gene as indicated in Illumina annotation.

b. Position relative to CpG Island as indicated in Illumina annotation.

c. Unadjusted mean.

d. All analyses adjusted for age, income, part/full-time status, occupational exposures to radiation and disinfectants, and leukocyte cell profile. Workers with <10 years of night shift work duration are the referent category.

e. Q-values represent p-values adjusted for multiple testing using the FDR method.