Table 3.
Side effects and adverse events.
| Article | Side Effects | Adverse Events | Withdrawals |
|---|---|---|---|
| Maurer et al.32 | |||
| Delta-9-THC | Not reported. | Not reported. | 0 |
| Codeine | Not reported. | Not reported. | |
| Hagenbach et al.35 | |||
| Dronabinol | n = 22∞ | Not reported. | 7 |
| Dry mouth (32%), Sleepiness (36%), Anxiety (32%) | |||
| Rintala et al.34 | |||
| Dronabinol | n = 7 | Not reported. | 2 |
| Dry mouth (71%), Constipation (71%), Fatigue (57%), Drowsiness (57%) | |||
| Diphenhydramine | n = 5 | Not reported. | 0 |
| Fatigue (100%), Dry mouth (60%), Constipation (60%), Drowsiness (60%) | |||
| GW Pharmaceuticals Ltd. 2012 | |||
| Nabiximols | n = 46 | n = 3 | 2 |
| Dizziness (30%), Disgeusia (20%) UTI (17%), Somnolence (15%), Nausea (13%), Headache (11%) | Anemia (33%), Fall (33%), Infections (33%), Tibia fracture (33%), Confusion (33%), Paranoia (33%) | ||
| Placebo | n = 29 | n = 2 | 1 |
| Dizziness (17%), Disgeusia (14%), UTI (14%), Nausea (10%), Oral pain (10%); Alanine aminotransferase increase (10%), Gamma-glutamyltransferase increase (10%) | Fall (50%), Bladder infection (50%), Pneumonia (50%), Upper limb fracture (50%), Dizziness (50%), Contusion (50%) | ||
| Wilsey et al.31 papers A & B | |||
| 2.9% and 6.7% delta-9 THC | Any drug effect, good drug effect, bad drug effect, high, drunk, impaired, stoned, like the drug effect, sedated, confused, nauseous, desired more, hungry, changes perceiving time, changes perceiving space, difficult paying attention, difficulty remembering things.*** |
n = 1 Syncopy (100%) |
0 |
∞ = ‘n’ includes drop-outs. UTI = Urinary Tract Infection. ***Side effects increased with concentrations of delta-9-THC.