FIGURE 3.

Examples of multiparametric functional NMR studies performed in a patient with mitochondrial diabetes (A) and another with peripheral artery disease (B). After a plantar flexion ischaemic bout, time curves of calf muscle perfusion (top), Mb resaturation (middle) and creatine rephosphorylation (bottom) were simultaneously monitored by interleaving ASL imaging and ¹H and ³¹P NMR spectroscopy, respectively. In both conditions, the creatine rephosphorylation rate, an indicator of mitochondrial ATP resynthesis, was abnormally low. In B, mitochondrial dysfunction was clearly attributable to a blunted functional hyperaemia (top) and a dramatically slow muscle reoxygenation (middle). In A, post‐exercise reperfusion and Mb resaturation were within normal ranges, indicating an intrinsic defect of mitochondrial function ⁷³