Table 2.
Twelve-month change in DNA methylation patterns.
| |
Control |
Exercise |
P-value* |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline |
12 Month |
Difference % |
Baseline |
12 Month |
Difference % |
|||||||||||||
| Gene | Sex | N | GM | 95% CI | N | GM | 95% CI | N | GM | 95% CI | N | GM | 95% CI | P_un | P[1] | P[2] | ||
| ESR1 | Men | 47 | 3.410 | (2.840, 4.0927 |
43 | 3.131 | (2.516, 3.897) |
−0.278 –8.16% |
50 | 3.774 | (3.124, 4.559) |
44 | 3.985 | 3.249 4.887 |
0.211 5.54% |
0.62 | 0.61 | 0.99 |
| Women | 51 | 2.760 | (2.197, 3.467) |
46 | 3.066 | (2.394, 3.926) |
0.306 11.10% |
48 | 2.451 | (1.959, 3.066) |
43 | 2.191 | 1.704 2.817 |
−0.259 –10.58% |
0.05 | 0.06 | 0.07 | |
| P interaction | 0.06 | 0.05 | 0.12 | |||||||||||||||
| EVL | Men | 47 | 0.270 | (0.181, 0.405) |
43 | 0.225 | (0.158, 0.318) |
−0.047 –17.25% |
50 | 0.284 | (0.206, 0.392) |
44 | 0.336 | 0.238 0.474 |
0.052 18.21% |
0.17 | 0.14 | 0.58 |
| Women | 51 | 0.286 | (0.203, 0.404) |
46 | 0.340 | (0.247, 0.494) |
0.063 21.90% |
48 | 0.266 | (0.201, 0.352) |
43 | 0.280 | 0.204 0.383 |
0.014 5.26% |
0.63 | 0.67 | 0.60 | |
| P interaction | 0.09 | 0.09 | 0.29 | |||||||||||||||
| p14ARF | Men | 47 | 0.016 | (0.011, 0.024) |
43 | 0.015 | (0.010, 0.021) |
−0.001 –7.03% |
50 | 0.021 | (0.015, 0.029) |
44 | 0.016 | 0.011 0.023 |
−0.004 –21.04% |
0.46 | 0.24 | 0.46 |
| Women | 51 | 0.014 | (0.010, 0.021) |
46 | 0.017 | (0.012, 0.025) |
0.003 20.63% |
48 | 0.010 | (0.007, 0.013) |
43 | 0.015 | 0.011 0.021 |
0.005 54.92% |
0.38 | 0.33 | 0.38 | |
| P interaction | 0.82 | 0.86 | 0.82 | |||||||||||||||
P_un: P-value based on GEE models comparing the 12-months changes in the DNA methylation between Controls versus participants in the Exercise group within each stratum of gender, unadjusted.
P1: P-value based on GEE models comparing the 12-months changes in the DNA methylation between Controls versus participants in the Exercise group within each stratum of gender, adjusted for age and baseline BMI (continuous).
P2: P-value based on GEE models comparing the 12-months changes in the DNA methylation between Controls versus participants in the Exercise group within each stratum of gender, adjusted for age, baseline BMI (continuous), history of adenomatous polyps, history of adenomatous polyps, folate, and vitamin B2, B6, and B12 intakes.
P Interaction is the P-value obtained from GEE model comparing the intervention effect on the DNA methylation between men and women.