Table 4.

Correlations between baseline (log-transformed) DNA methylation patterns and baseline variables in men.

	ESR1			EVL			p14ARF
	N	Rho	P	N	Rho	P	N	Rho	P
Bax density
Crypt bottom	94	−0.116	0.26	94	−0.118	0.26	94	−0.112	0.29
Crypt middle	94	−0.140	0.18	94	−0.124	0.24	94	−0.107	0.30
Crypt top	94	−0.138	0.18	94	−0.104	0.32	94	−0.097	0.35
Crypt whole	94	−0.137	0.19	94	−0.118	0.26	94	−0.108	0.30
Crypt height	94	0.091	0.39	94	0.013	0.90	94	−0.039	0.70
Bcl-2 density
Crypt bottom	94	−0.123	0.236	94	−0.094	0.367	94	−0.146	0.16
Crypt middle	94	−0.141	0.176	94	−0.068	0.515	94	−0.190	0.07
Crypt top	94	−0.117	0.261	94	−0.043	0.681	94	−0.053	0.60
Crypt whole	94	−0.140	0.180	94	−0.072	0.492	94	−0.134	0.19
Crypt height	94	0.033	0.750	94	−0.073	0.486	94	−0.113	0.28
Bax/bcl-2
Crypt bottom	92	−0.009	0.93	92	0.030	0.78	92	−0.009	0.93
Crypt middle	92	0.004	0.97	92	0.063	0.55	92	−0.060	0.57
Crypt top	92	0.027	0.79	92	0.061	0.56	92	0.054	0.61
Crypt whole	92	0.012	0.91	92	0.061	0.57	92	0.003	0.98
Crypt height	96	0.066	0.52	96	−0.037	0.72	96	−0.085	0.41
Ki67+ cells
Average cell height	96	0.008	0.94	96	−0.097	0.35	96	−0.119	0.25
Median cell height	96	0.014	0.89	96	−0.116	0.26	96	−0.104	0.31
75th percentile cell height	96	0.017	0.87	96	−0.074	0.47	96	−0.099	0.34
Weighted average cell height	96	0.028	0.79	96	−0.069	0.50	96	0.010	0.92
Average crypt height from KI67 slice	96	−0.013	0.89	96	−0.080	0.44	96	−0.189	0.07
Average percent cell height	96	0.042	0.69	96	−0.047	0.65	96	0.023	0.82
Median percent cell height	96	0.036	0.73	96	−0.075	0.47	96	0.024	0.81
75th percentile percent cell height	96	0.044	0.67	96	−0.024	0.82	96	0.051	0.62
Cytokeratin-18	97	0.045	0.66	97	0.043	0.68	97	−0.085	0.41
Circulating biomarkers
Insulin	97	−0.100	0.330	97	−0.088	0.39	97	−0.008	0.95
Glucose	97	0.027	0.795	97	−0.023	0.82	97	−0.044	0.67
HOMA (Homoeostatic Model Assessment)	97	−0.094	0.359	97	−0.089	0.39	97	−0.013	0.89
CRP (C-reactive Protein)	93	−0.070	0.502	93	−0.097	0.36	93	−0.055	0.60
Testosterone	97	−0.196	0.055	97	−0.125	0.22	97	−0.100	0.33
Free testosterone	97	−0.227	0.026	97	−0.097	0.35	97	−0.109	0.29
SHBG (Sex Steroid Hormone Binding Globulin)	97	−0.089	0.387	97	−0.132	0.20	97	−0.065	0.50
DHT (5α-dihydrotestosterone)	97	−0.087	0.40	97	−0.065	0.52	97	−0.085	0.41