Table 4.

Optimal cutoff values and sensitivity and specificity of NSE, IL-6, and APACHE II score for predicting prognosis in patients with septic shock.

	Cutoff value	Sensitivity	Specificity	Positive likelihood ratio	Negative likelihood ratio
NSE (day1) (ug/L)	27.46	61.11 (95% CI: 35.7–82.7)	87.72 (95% CI: 76.3–94.9)	4.98	0.44
NSE (day4) (ug/L)	25.94	61.11 (95% CI: 35.7–82.7)	91.23 (95% CI: 80.7–97.1)	6.97	0.43
IL-6 (pg/mL)	869.7	50.00 (95% CI: 26.0–74.0)	85.96 (95% CI: 74.2–93.7)	3.56	0.58
APACHE II score	18	72.22 (95% CI: 46.5–90.3)	56.14 (95% CI: 42.4–69.3)	1.65	0.49

APACHE II score = acute physiology and chronic health evaluation II score, CI = confidence interval, IL-6 = interleukin-6, NSE = neuron-specific enolase.