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. 2022 Feb 23;18(10):2368–2384. doi: 10.1080/15548627.2022.2034131

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Protein array analysis of autophagy pathways in the RPE. Reverse phase protein array analysis was used to quantify protein expression changes in the autophagy pathways in the RPE from WT- (gray bars) and APOE-mice (black bars) treated with trehalose and metformin. Results are shown for (A) SRC, (B) AKT, (C) AKT phosphorylated at T306, (D) TSC2/tuberin, (E) ATM, (F) AMPK, (G) MTOR, (H) MTOR phosphorylated at S2448, (I) RPS6KB/p70 S6 kinase, (J) CCNE1, (K-L) EIF4EBP1 phophorylated at (K) S65 and (L) T37, T46, (M) SQSTM1/p62, (N) MAPK14/p38 phosphorylated at T180, (O) PHB, (P) BCL2L1, and (Q) TP53. For all groups, n = 5; Two way ANOVA with post-hoc significance of p < 0.05 shown for genotype (*) and treatment (#).