Figure 7.
EAE severity in mice after diet switch from phyto-free (PF) to isoflavone-rich (ISO) and ISO to PF diet. Mice were kept for six weeks on PF/ISO diet until day −28 where diet was switched for four weeks. After the diet switch EAE was induced using MOG35-55.a) Experimental outline of dietary regime and EAE induction in mice and clinical monitoring of EAE scores. b) Average clinical EAE scores of mice in which diet was changed from PF to ISO (PF_ISO n =8) and ISO to PF (ISO_PF n =10) for 41days post EAE induction. c) Kaplan-Meier survival analysis of mice after EAE induction for 41days.